| Date | Location | Result | |
| 03/03/06 | Memorial Center (Johnson City, Tenn.) | Gardner-Webb 64, ETSU 63 | Box score |
| 2/26/06 | Nashville, Tenn. (Curb Event Center) | Belmont 99, ETSU 78 | |
| 02/24/06 | Nashville, Tenn. | Lipscomb 76, ETSU 56 | |
| 02/16/06 | Boca Raton, Fla. | Florida Atlantic 93, ETSU 87 | |
| 2/11/06 | Johnson City, Tenn. (Memorial Center) | Gardner-Webb 69, ETSU 64 | Box score |
| 2/9/06 | Johnson City, Tenn. (Memorial Center) | ETSU 89, Campbell 81 | Box score |
| 2/5/06 | Jacksonville, Fla. (UNF Arena) | ETSU 99, North Florida 83 | |
| 2/3/06 | Jacksonville, Fla. (Swisher Gymnasium) | East Tenn. State 88, Jacksonville 73 | |
| 1/30/06 | Johnson City, Tenn. (Memorial Center) | ETSU 84, Mercer 81 | |
| 01/28/06 | Memorial Center (Johnson City, Tenn.) | Stetson 74, ETSU 71 | |
| 01/25/06 | Memorial Center (Johnson City, Tenn.) | ETSU 110, Kennesaw State 74 | |
| 01-21-06 | Macon, Ga. (University Center) | ETSU 104, MER 81 | |
| 01/19/06 | DeLand, Fla. -- Edmunds Center | ETSU 81, Stetson 72 | |
| 01/16/06 | Memorial Center (Johnson City, Tenn.) | ETSU 86, UNF 71 | Box score |
| 01/14/06 | Memorial Center (Johnson City, Tenn.) | ETSU 98, Jacksonville University 87 | |
| 01/12/06 | Kennesaw, GA - KSU Convocation Center | Kennesaw State 78, East Tennessee State 72 | Box score |
| 01/09/06 | Boiling Springs, NC / Paul Porter Arena | ETSU 89, Gardner-Webb 66 | |
| 01/07/06 | Buies Creek, N.C. / Carter Gym | East Tennessee State 110, Campbell 96 | |
| 01/04/06 | Memorial Center (Johnson City, Tenn.) | ETSU 63, FAU 61 | |
| 12/29/05 | Memorial Center (Johnson City, Tenn.) | ETSU 82, Morehead State 70 | Box score |
| 12/21/05 | Johnson City, Tenn. (Memorial Center) | ETSU 69, CMU 57 | Box score |
| 11/17/05 | Clarksville, Tenn. (Dave Aaron Arena) | Austin Peay 84, East Tennessee 71 | |
| 12/9/05 | Clemson, SC (Littlejohn Coliseum) | Clemson 80, East Tennessee State 72 | |
| 12/03/05 | Johnson City, Tenn. (Memorial Center) | LIP 56, ETSU 54 | Box score |
| 12/1/05 | Johnson City, Tenn. - Memorial Center | BEL 88, ETSU 85 | |
| 11/28/05 | Memorial Center (Johnson City, Tenn.) | ETSU 91, MARSHALL 63 | Box score |
| 11/22/05 | Radford, Va. -- Dedmon Center | Radford 95, ETSU 85 | |
| 11/18/05 | Thompson-Boling Arena (Knoxville, Tenn.) | Tennessee 106, East Tennessee State 83 |